Mental health and its associations with glucose-lowering medication in women with gestational diabetes mellitus. A prospective clinical cohort study.
Options
BORIS DOI
Publisher DOI
PubMed ID
33321330
Description
AIMS
Mental health symptoms are frequent in women with gestational diabetes mellitus (GDM) and may influence glycemic control. We therefore investigated if mental health symptoms (high depression and low well-being scores) predicted a need for glucose-lowering medication and if this use of medication influenced the trajectory of mental health during pregnancy and in the postpartum period.
METHODS
We included 341 pregnant women from a cohort of GDM women in a Swiss University Hospital. The World Health Organization Well-being Index-Five was collected at the first and last GDM and at the postpartum clinical visits and the Edinburgh Postnatal Depression Scale at the first GDM and the postpartum clinical visits. Medication intake was extracted from participants' medical records. We conducted linear and logistic regressions with depression as an interaction factor.
RESULTS
Mental health symptoms did not predict a need for medication (all p ≥ 0.29). Mental health improved over time (both p ≤ 0.001) and use of medication did not predict this change (all p ≥ 0.40). In women with symptoms of depression, medication was associated with less improvement in well-being at the postpartum clinical visit (p for interaction=0.013).
CONCLUSIONS
Mental health and glucose-lowering medication did not influence each other in an unfavourable way in this cohort of women with GDM.
Mental health symptoms are frequent in women with gestational diabetes mellitus (GDM) and may influence glycemic control. We therefore investigated if mental health symptoms (high depression and low well-being scores) predicted a need for glucose-lowering medication and if this use of medication influenced the trajectory of mental health during pregnancy and in the postpartum period.
METHODS
We included 341 pregnant women from a cohort of GDM women in a Swiss University Hospital. The World Health Organization Well-being Index-Five was collected at the first and last GDM and at the postpartum clinical visits and the Edinburgh Postnatal Depression Scale at the first GDM and the postpartum clinical visits. Medication intake was extracted from participants' medical records. We conducted linear and logistic regressions with depression as an interaction factor.
RESULTS
Mental health symptoms did not predict a need for medication (all p ≥ 0.29). Mental health improved over time (both p ≤ 0.001) and use of medication did not predict this change (all p ≥ 0.40). In women with symptoms of depression, medication was associated with less improvement in well-being at the postpartum clinical visit (p for interaction=0.013).
CONCLUSIONS
Mental health and glucose-lowering medication did not influence each other in an unfavourable way in this cohort of women with GDM.
Date of Publication
2021-02
Publication Type
Article
Keyword(s)
Depression Insulin Metformin Postpartum Pregnancy Well-being
Language(s)
en
Contributor(s)
Gilbert, Leah | |
Nikolaou, Argyro | |
Quansah, Dan Yedu | |
Horsch, Antje | |
Puder, Jardena J |
Additional Credits
Series
Psychoneuroendocrinology
Publisher
Elsevier
ISSN
0306-4530
Access(Rights)
open.access