Prospective validation of prognostic and diagnostic syncope scores in the emergency department.

DOI
Publisher DOI
PubMed ID
30224031
Abstract
BACKGROUND

Various scores have been derived for the assessment of syncope patients in the emergency department (ED) but stay inconsistently validated. We aim to compare their performance to the one of a common, easy-to-use CHADS score.

METHODS

We prospectively enrolled patients ≥ 40 years old presenting with syncope to the ED in a multicenter study. Early clinical judgment (ECJ) of the treating ED-physician regarding the probability of cardiac syncope was quantified. Two independent physicians adjudicated the final diagnosis after 1-year follow-up. Major cardiovascular events (MACE) and death were recorded during 2 years of follow-up. Nine scores were compared by their area under the receiver-operator characteristics curve (AUC) for death, MACE or the diagnosis of cardiac syncope.

RESULTS

1490 patients were available for score validation. The CHADS-score presented a higher or equally high accuracy for death in the long- and short-term follow-up than other syncope-specific risk scores. This score also performed well for the prediction of MACE in the long- and short-term evaluation and stratified patients with accuracy comparative to OESIL, one of the best performing syncope-specific risk score. All scores performed poorly for diagnosing cardiac syncope when compared to the ECJ.

CONCLUSIONS

The CHADS-score performed comparably to more complicated syncope-specific risk scores in the prediction of death and MACE in ED syncope patients. While better tools incorporating biochemical and electrocardiographic markers are needed, this study suggests that the CHADS-score is currently a good option to stratify risk in syncope patients in the ED.

TRIAL REGISTRATION

NCT01548352.
Date Issued
2018-10-15
Publication Type
Article
Subject(s)
Subjects
Diagnosis Emergency department Scores Syncope
Language(s)
en
Author(s)
du Fay de Lavallaz, Jeanne
Badertscher, Patrick
Nestelberger, Thomas
Isenrich, Rahel
Miró, Òscar
Salgado, Emilio
Geigy, Nicolas
Christ, Michael
Cullen, Louise
Than, Martin
Martin-Sanchez, F Javier
Bustamante Mandrión, José
Di Somma, Salvatore
Peacock, W Frank
Kawecki, Damian
Boeddinghaus, Jasper
Twerenbold, Raphael
Puelacher, Christian
Wussler, Desiree
Strebel, Ivo
Keller, Dagmar I
Poepping, Imke
Kühne, Michael
Mueller, Christian
Additional Credits
Journal
International journal of cardiology
Publisher
Elsevier
ISSN
0167-5273
Access(Rights)
restricted
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