EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders.
Publisher DOI
PubMed ID
25819018
Abstract
Biologic agents (also termed biologicals or biologics) are therapeutics that are synthesized by living organisms and directed against a specific determinant, for example, a cytokine or receptor. In inflammatory and autoimmune diseases, biologicals have revolutionized the treatment of several immune-mediated disorders. Biologicals have also been tested in allergic disorders. These include agents targeting IgE; T helper 2 (Th2)-type and Th2-promoting cytokines, including interleukin-4 (IL-4), IL-5, IL-9, IL-13, IL-31, and thymic stromal lymphopoietin (TSLP); pro-inflammatory cytokines, such as IL-1β, IL-12, IL-17A, IL-17F, IL-23, and tumor necrosis factor (TNF); chemokine receptor CCR4; and lymphocyte surface and adhesion molecules, including CD2, CD11a, CD20, CD25, CD52, and OX40 ligand. In this task force paper of the Interest Group on Biologicals of the European Academy of Allergy and Clinical Immunology, we review biologicals that are currently available or tested for the use in various allergic and urticarial pathologies, by providing an overview on their state of development, area of use, adverse events, and future research directions.
Date Issued
2015-07
Publication Type
Article
Subject(s)
Subjects
allergic rhinitis
•
asthma
•
atopic dermatitis
•
eosinophilic disorders
•
food allergy
•
hymenoptera allergy
•
urticaria
Language(s)
en
Author(s)
Boyman, O | |
Kaegi, C | |
Akdis, M | |
Bavbek, S | |
Bossios, A | |
Chatzipetrou, A | |
Eiwegger, T | |
Firinu, D | |
Harr, T | |
Knol, E | |
Matucci, A | |
Palomares, O | |
Schmidt-Weber, C | |
Steiner, U C | |
Vultaggio, A | |
Akdis, C A | |
Spertini, F |
Additional Credits
Journal
Allergy
Publisher
Wiley-Blackwell
ISSN
0105-4538
Access(Rights)
restricted