Current challenges facing the assessment of the allergenic capacity of food allergens in animal models.

DOI
Publisher DOI
PubMed ID
27313841
Abstract
Food allergy is a major health problem of increasing concern. The insufficiency of protein sources for human nutrition in a world with a growing population is also a significant problem. The introduction of new protein sources into the diet, such as newly developed innovative foods or foods produced using new technologies and production processes, insects, algae, duckweed, or agricultural products from third countries, creates the opportunity for development of new food allergies, and this in turn has driven the need to develop test methods capable of characterizing the allergenic potential of novel food proteins. There is no doubt that robust and reliable animal models for the identification and characterization of food allergens would be valuable tools for safety assessment. However, although various animal models have been proposed for this purpose, to date, none have been formally validated as predictive and none are currently suitable to test the allergenic potential of new foods. Here, the design of various animal models are reviewed, including among others considerations of species and strain, diet, route of administration, dose and formulation of the test protein, relevant controls and endpoints measured.
Date Issued
2016
Publication Type
Article
Subjects
Animal models
•
Food allergy
•
Hazard identification
•
Novel allergens
Language(s)
en
Author(s)
Bøgh, Katrine Lindholm
van Bilsen, Jolanda
Głogowski, Robert
López-Expósito, Iván
Bouchaud, Grégory
Blanchard, Carine
Bodinier, Marie
Smit, Joost
Pieters, Raymond
Bastiaan-Net, Shanna
de Wit, Nicole
Untersmayr, Eva
Adel-Patient, Karine
Knippels, Leon
Epstein, Michelle M
Nygaard, Unni Cecilie
Kimber, Ian
Verhoeckx, Kitty
O'Mahony, Liam
Additional Credits
Journal
Clinical and translational allergy
Publisher
BioMed Central
ISSN
2045-7022
Access(Rights)
Unknown
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