Ectodysplasin-1 deficiency in a German Holstein bull associated with loss of respiratory mucous glands and chronic rhinotracheitis

DOI
Publisher DOI
PubMed ID
15893993
Abstract
A 2-year-old German Holstein bull was identified as a carrier of a mutation within the X-chromosomal ED1 gene, which encodes a TNF-related signalling molecule mainly involved in ectodermal development. The clinicopathological appearance was associated with hypotrichosis, hypodontia, and a reduced number of eccrine glands, in addition to chronic rhinotracheitis and partial squamous metaplasia. Furthermore, for the first time in an ED1-deficient animal, a complete lack of respiratory mucous glands was observed. This suggests that the ED1 gene plays a role in the development of mucous glands, the absence of which resembles a feature of X-linked anhidrotic ectodermal dysplasia (ED1) in human patients.
Date Issued
2005-05
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Seeliger, F
Tegtmeier, P
Baumgärtner, W
Distl, O
Additional Credits
Journal
Journal of comparative pathology
Publisher
Elsevier
ISSN
0021-9975
Access(Rights)
restricted
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