Regulation of mitochondrial function by hypoxia and inflammation in sepsis: A putative role for hypoxia inducible factor
Publisher DOI
Abstract
Sepsis-related organ failure is the leading cause of mortality in European intensive care units (ICU). Although the inflammatory cascade of mediators in response to infection is well known, the relationships between regional inflammation, microvascular heterogeneity, hypoxia and hypoxia-inducible gene expression, and finally, organ dysfunction, are unknown. Growing evidence suggests that not only low oxygen supply to the tissues secondary to macrovascular and microvascular alterations, but also altered cellular oxygen utilization is involved in the development of multiorgan dysfunction [1]–[3]. Microbial products and innate and adaptive dysregulated immune response to infection directly affect parenchymal cells of organs and may contribute to multiorgan dysfunction.
Date Issued
2008
Publication Type
Book Section
Subject(s)
Language(s)
en
Editor(s)
Vincent, Jean-Louis |
Publisher
Springer
ISBN
978-3-540-77290-3
Access(Rights)
metadata.only