-File: Protocol

The Scoping Review protocol is reported.

-File: Search strings

The search strings are reported.

-Files: "Abstract selection" and "Full-text selection_cat A_cat B_excluded_scores-scales"

The papers found after the literature search underwent an abstract selection. 
The remaining underwent a full-text selection.

Papers passed the abstract selection phase if their abstract:
1.	reported original research; 
2.	performed using pigs or minipigs; 
3.	performed in vivo; 
4.	involved animals undergoing general anaesthesia.
5.      reported at least one depth of anaesthesia indicator

Full-text papers were excluded if: 
-	the authors did not report any DoA indicator;
-	the DoA indicators were not reported for at least two well distinct time points and/or drug combinations and/or drug concentrations and/or physiological conditions and/or surgical interventions;
-	unconsciousness was not pharmacologically induced (e.g., electricity, carbon dioxide);
-	only a minimum alveolar concentration (MAC) extrapolated from other studies was used to guide anaesthetic administration;
-	the paper was found to be a duplicate, or at least one of the five abstract inclusion criteria was not fulfilled;
-	only the abstract was available.

From the included papers, DoA indicators were identified and categorized as follows: 
-	category A: indicators purposely investigated as method to assess depth of anaesthesia; 
-	category B: indicators reported but not investigated as method to assess depth of anaesthesia.


The paper has been submitted to PlosOne.